Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV
Identifieur interne : 004753 ( Main/Exploration ); précédent : 004752; suivant : 004754Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV
Auteurs : Zhi-Gang Wang [République populaire de Chine] ; Zhi-Hua Zheng [République populaire de Chine] ; Lei Shang [République populaire de Chine] ; Lan-Juan Li [République populaire de Chine] ; Li-Ming Cong [République populaire de Chine] ; Ming-Guang Feng [République populaire de Chine] ; Yun Luo [République populaire de Chine] ; Su-Yun Cheng [République populaire de Chine] ; Yan-Jun Zhang [République populaire de Chine] ; Miao-Gui Ru [République populaire de Chine] ; Zan-Xin Wang [République populaire de Chine] ; Qi-Yu Bao [République populaire de Chine]Source :
- Febs Letters [ 0014-5793 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- classification : SARS Virus.
- genetics : SARS Virus.
- pathogenicity : SARS Virus.
- Base Sequence, Databases, Nucleic Acid, Evolution, Molecular, Genotype, Humans, Molecular Sequence Data, Phylogeny, Polymorphism, Genetic, Selection, Genetic, Sequence Analysis, DNA.
Abstract
In this study, we have identified 876 polymorphism sites in 145 complete or partial genomes of SARS-CoV available in the NCBI GenBank. One hundred and seventy-four of these sites existed in two or more SARS-CoV genome sequences. According to the sequence polymorphism, all SARS-CoVs can be divided into three groups: (I) group 1, animal-origin viruses (such as SARS-CoV SZ1, SZ3, SZ13 and SZ16); (II) group 2, all viruses with clinical origin during first epidemic; and (III) group 3, SARS-CoV GD03T0013. According to 10 special loci, group 2 again can be divided into genotypes C and T, which can be further divided into sub-genotypes C1–C4 and T1–T4. Positive Darwinian selections were identified between any pair of these three groups. Genotype C gives neutral selection. Genotype T, however, shows negative selection. By comparing the death rates of SARS patients in the different regions, it was found that the death rate caused by the viruses of the genotype C was lower than that of the genotype T. SARS-CoVs might originate from an unknown ancestor.
Url:
DOI: 10.1016/j.febslet.2005.07.075
PubMed: 16112670
PubMed Central: 7118731
Affiliations:
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Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. 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Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Institute of Biomedical Informatics, Wenzhou Medical College, Wenzhou 325000, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Biomedical Informatics, Wenzhou Medical College, Wenzhou 325000</wicri:regionArea><wicri:noRegion>Wenzhou 325000</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16112670</idno><idno type="pmc">7118731</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118731</idno><idno type="RBID">PMC:7118731</idno><idno type="doi">10.1016/j.febslet.2005.07.075</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000879</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000879</idno><idno type="wicri:Area/Pmc/Curation">000879</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000879</idno><idno type="wicri:Area/Pmc/Checkpoint">001295</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001295</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:16112670</idno><idno type="wicri:Area/PubMed/Corpus">002577</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002577</idno><idno type="wicri:Area/PubMed/Curation">002577</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002577</idno><idno type="wicri:Area/PubMed/Checkpoint">002619</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002619</idno><idno type="wicri:Area/Ncbi/Merge">001125</idno><idno type="wicri:Area/Ncbi/Curation">001125</idno><idno type="wicri:Area/Ncbi/Checkpoint">001125</idno><idno type="wicri:doubleKey">0014-5793:2005:Wang Z:molecular:evolution:and</idno><idno type="wicri:Area/Main/Merge">004A29</idno><idno type="wicri:Area/Main/Curation">004753</idno><idno type="wicri:Area/Main/Exploration">004753</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV</title><author><name sortKey="Wang, Zhi Gang" sort="Wang, Zhi Gang" uniqKey="Wang Z" first="Zhi-Gang" last="Wang">Zhi-Gang Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zheng, Zhi Hua" sort="Zheng, Zhi Hua" uniqKey="Zheng Z" first="Zhi-Hua" last="Zheng">Zhi-Hua Zheng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Shang, Lei" sort="Shang, Lei" uniqKey="Shang L" first="Lei" last="Shang">Lei Shang</name><affiliation wicri:level="4"><nlm:aff id="aff2">James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Li, Lan Juan" sort="Li, Lan Juan" uniqKey="Li L" first="Lan-Juan" last="Li">Lan-Juan Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Cong, Li Ming" sort="Cong, Li Ming" uniqKey="Cong L" first="Li-Ming" last="Cong">Li-Ming Cong</name><affiliation wicri:level="1"><nlm:aff id="aff1">Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Feng, Ming Guang" sort="Feng, Ming Guang" uniqKey="Feng M" first="Ming-Guang" last="Feng">Ming-Guang Feng</name><affiliation wicri:level="4"><nlm:aff id="aff2">James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Luo, Yun" sort="Luo, Yun" uniqKey="Luo Y" first="Yun" last="Luo">Yun Luo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Cheng, Su Yun" sort="Cheng, Su Yun" uniqKey="Cheng S" first="Su-Yun" last="Cheng">Su-Yun Cheng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhang, Yan Jun" sort="Zhang, Yan Jun" uniqKey="Zhang Y" first="Yan-Jun" last="Zhang">Yan-Jun Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Ru, Miao Gui" sort="Ru, Miao Gui" uniqKey="Ru M" first="Miao-Gui" last="Ru">Miao-Gui Ru</name><affiliation wicri:level="1"><nlm:aff id="aff1">Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Wang, Zan Xin" sort="Wang, Zan Xin" uniqKey="Wang Z" first="Zan-Xin" last="Wang">Zan-Xin Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Bao, Qi Yu" sort="Bao, Qi Yu" uniqKey="Bao Q" first="Qi-Yu" last="Bao">Qi-Yu Bao</name><affiliation wicri:level="4"><nlm:aff id="aff2">James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Institute of Biomedical Informatics, Wenzhou Medical College, Wenzhou 325000, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Biomedical Informatics, Wenzhou Medical College, Wenzhou 325000</wicri:regionArea><wicri:noRegion>Wenzhou 325000</wicri:noRegion></affiliation></author></analytic><series><title level="j">Febs Letters</title><idno type="ISSN">0014-5793</idno><idno type="eISSN">1873-3468</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence</term><term>Databases, Nucleic Acid</term><term>Evolution, Molecular</term><term>Genotype</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Polymorphism, Genetic</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (pathogenicity)</term><term>Selection, Genetic</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Bases de données d'acides nucléiques</term><term>Données de séquences moléculaires</term><term>Génotype</term><term>Humains</term><term>Phylogénie</term><term>Polymorphisme génétique</term><term>Sélection génétique</term><term>Séquence nucléotidique</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (pathogénicité)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term><term>Databases, Nucleic Acid</term><term>Evolution, Molecular</term><term>Genotype</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Polymorphism, Genetic</term><term>Selection, Genetic</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Bases de données d'acides nucléiques</term><term>Données de séquences moléculaires</term><term>Génotype</term><term>Humains</term><term>Phylogénie</term><term>Polymorphisme génétique</term><term>Sélection génétique</term><term>Séquence nucléotidique</term><term>Virus du SRAS</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this study, we have identified 876 polymorphism sites in 145 complete or partial genomes of SARS-CoV available in the NCBI GenBank. One hundred and seventy-four of these sites existed in two or more SARS-CoV genome sequences. According to the sequence polymorphism, all SARS-CoVs can be divided into three groups: (I) group 1, animal-origin viruses (such as SARS-CoV SZ1, SZ3, SZ13 and SZ16); (II) group 2, all viruses with clinical origin during first epidemic; and (III) group 3, SARS-CoV GD03T0013. According to 10 special loci, group 2 again can be divided into genotypes C and T, which can be further divided into sub-genotypes C1–C4 and T1–T4. Positive Darwinian selections were identified between any pair of these three groups. Genotype C gives neutral selection. Genotype T, however, shows negative selection. By comparing the death rates of SARS patients in the different regions, it was found that the death rate caused by the viruses of the genotype C was lower than that of the genotype T. SARS-CoVs might originate from an unknown ancestor.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Groneberg, D A" uniqKey="Groneberg D">D.A. Groneberg</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Welte, T" uniqKey="Welte T">T. Welte</name></author><author><name sortKey="Zabel, P" uniqKey="Zabel P">P. Zabel</name></author><author><name sortKey="Chung, K F" uniqKey="Chung K">K.F. Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yam, L Y" uniqKey="Yam L">L.Y. Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J. Nicholls</name></author><author><name sortKey="Yee, W K" uniqKey="Yee W">W.K. Yee</name></author><author><name sortKey="Yan, W W" uniqKey="Yan W">W.W. Yan</name></author><author><name sortKey="Cheung, M T" uniqKey="Cheung M">M.T. Cheung</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Tsang, D N" uniqKey="Tsang D">D.N. Tsang</name></author><author><name sortKey="Yung, R W" uniqKey="Yung R">R.W. Yung</name></author><author><name sortKey="Ng, T K" uniqKey="Ng T">T.K. Ng</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M. Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L. Kolesnikova</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A. Berger</name></author><author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A.M. Burguiere</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name></author><author><name sortKey="Kramme, S" uniqKey="Kramme S">S. Kramme</name></author><author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J.C. Manuguerra</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S. Muller</name></author><author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V. Rickerts</name></author><author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M. Sturmer</name></author><author><name sortKey="Vieth, S" uniqKey="Vieth S">S. Vieth</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D. Erdman</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T. Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S. Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S. Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C. Urbani</name></author><author><name sortKey="Comer, J A" uniqKey="Comer J">J.A. Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Rollin, P E" uniqKey="Rollin P">P.E. Rollin</name></author><author><name sortKey="Dowell, S F" uniqKey="Dowell S">S.F. Dowell</name></author><author><name sortKey="Ling, A E" uniqKey="Ling A">A.E. Ling</name></author><author><name sortKey="Humphrey, C D" uniqKey="Humphrey C">C.D. Humphrey</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J. Guarner</name></author><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C.D. Paddock</name></author><author><name sortKey="Rota, P" uniqKey="Rota P">P. Rota</name></author><author><name sortKey="Fields, B" uniqKey="Fields B">B. Fields</name></author><author><name sortKey="Derisi, J" uniqKey="Derisi J">J. DeRisi</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J.Y. Yang</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N. Cox</name></author><author><name sortKey="Hughes, J M" uniqKey="Hughes J">J.M. Hughes</name></author><author><name sortKey="Leduc, J W" uniqKey="Leduc J">J.W. LeDuc</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.J. Zheng</name></author><author><name sortKey="He, Y Q" uniqKey="He Y">Y.Q. He</name></author><author><name sortKey="Liu, X L" uniqKey="Liu X">X.L. Liu</name></author><author><name sortKey="Zhuang, Z X" uniqKey="Zhuang Z">Z.X. Zhuang</name></author><author><name sortKey="Cheung, C L" uniqKey="Cheung C">C.L. Cheung</name></author><author><name sortKey="Luo, S W" uniqKey="Luo S">S.W. Luo</name></author><author><name sortKey="Li, P H" uniqKey="Li P">P.H. Li</name></author><author><name sortKey="Zhang, L J" uniqKey="Zhang L">L.J. Zhang</name></author><author><name sortKey="Guan, Y J" uniqKey="Guan Y">Y.J. Guan</name></author><author><name sortKey="Butt, K M" uniqKey="Butt K">K.M. Butt</name></author><author><name sortKey="Wong, K L" uniqKey="Wong K">K.L. Wong</name></author><author><name sortKey="Chan, K W" uniqKey="Chan K">K.W. Chan</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Shortridge, K F" uniqKey="Shortridge K">K.F. Shortridge</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stadler, K" uniqKey="Stadler K">K. Stadler</name></author><author><name sortKey="Masignani, V" uniqKey="Masignani V">V. Masignani</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Abrignani, S" uniqKey="Abrignani S">S. Abrignani</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name></author><author><name sortKey="Rappuoli, R" uniqKey="Rappuoli R">R. Rappuoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name></author><author><name sortKey="Yan, M" uniqKey="Yan M">M. Yan</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L. Yang</name></author><author><name sortKey="Ding, B" uniqKey="Ding B">B. Ding</name></author><author><name sortKey="He, B" uniqKey="He B">B. He</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name></author><author><name sortKey="You, B" uniqKey="You B">B. You</name></author><author><name sortKey="Huang, S" uniqKey="Huang S">S. Huang</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Mu, F" uniqKey="Mu F">F. Mu</name></author><author><name sortKey="Xiang, Z" uniqKey="Xiang Z">Z. Xiang</name></author><author><name sortKey="Feng, X" uniqKey="Feng X">X. Feng</name></author><author><name sortKey="Wen, J" uniqKey="Wen J">J. Wen</name></author><author><name sortKey="Fang, J" uniqKey="Fang J">J. Fang</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J. Yu</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antia, R" uniqKey="Antia R">R. Antia</name></author><author><name sortKey="Regoes, R R" uniqKey="Regoes R">R.R. Regoes</name></author><author><name sortKey="Koella, J C" uniqKey="Koella J">J.C. Koella</name></author><author><name sortKey="Bergstrom, C T" uniqKey="Bergstrom C">C.T. Bergstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, P L" uniqKey="Lim P">P.L. Lim</name></author><author><name sortKey="Kurup, A" uniqKey="Kurup A">A. Kurup</name></author><author><name sortKey="Gopalakrishna, G" uniqKey="Gopalakrishna G">G. Gopalakrishna</name></author><author><name sortKey="Chan, K P" uniqKey="Chan K">K.P. Chan</name></author><author><name sortKey="Wong, C W" uniqKey="Wong C">C.W. Wong</name></author><author><name sortKey="Ng, L C" uniqKey="Ng L">L.C. Ng</name></author><author><name sortKey="Se Thoe, S Y" uniqKey="Se Thoe S">S.Y. Se-Thoe</name></author><author><name sortKey="Oon, L" uniqKey="Oon L">L. Oon</name></author><author><name sortKey="Bai, X" uniqKey="Bai X">X. Bai</name></author><author><name sortKey="Stanton, L W" uniqKey="Stanton L">L.W. Stanton</name></author><author><name sortKey="Ruan, Y" uniqKey="Ruan Y">Y. Ruan</name></author><author><name sortKey="Miller, L D" uniqKey="Miller L">L.D. Miller</name></author><author><name sortKey="Vega, V B" uniqKey="Vega V">V.B. Vega</name></author><author><name sortKey="James, L" uniqKey="James L">L. James</name></author><author><name sortKey="Ooi, P L" uniqKey="Ooi P">P.L. Ooi</name></author><author><name sortKey="Kai, C S" uniqKey="Kai C">C.S. Kai</name></author><author><name sortKey="Olsen, S J" uniqKey="Olsen S">S.J. Olsen</name></author><author><name sortKey="Ang, B" uniqKey="Ang B">B. Ang</name></author><author><name sortKey="Leo, Y S" uniqKey="Leo Y">Y.S. Leo</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ruan, Y J" uniqKey="Ruan Y">Y.J. Ruan</name></author><author><name sortKey="Wei, C L" uniqKey="Wei C">C.L. Wei</name></author><author><name sortKey="Ee, A L" uniqKey="Ee A">A.L. Ee</name></author><author><name sortKey="Vega, V B" uniqKey="Vega V">V.B. Vega</name></author><author><name sortKey="Thoreau, H" uniqKey="Thoreau H">H. Thoreau</name></author><author><name sortKey="Su, S T" uniqKey="Su S">S.T. Su</name></author><author><name sortKey="Chia, J M" uniqKey="Chia J">J.M. Chia</name></author><author><name sortKey="Ng, P" uniqKey="Ng P">P. Ng</name></author><author><name sortKey="Chiu, K P" uniqKey="Chiu K">K.P. Chiu</name></author><author><name sortKey="Lim, L" uniqKey="Lim L">L. Lim</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T. Zhang</name></author><author><name sortKey="Peng, C K" uniqKey="Peng C">C.K. Peng</name></author><author><name sortKey="Lin, E O" uniqKey="Lin E">E.O. Lin</name></author><author><name sortKey="Lee, N M" uniqKey="Lee N">N.M. Lee</name></author><author><name sortKey="Yee, S L" uniqKey="Yee S">S.L. Yee</name></author><author><name sortKey="Ng, L F" uniqKey="Ng L">L.F. Ng</name></author><author><name sortKey="Chee, R E" uniqKey="Chee R">R.E. Chee</name></author><author><name sortKey="Stanton, L W" uniqKey="Stanton L">L.W. Stanton</name></author><author><name sortKey="Long, P M" uniqKey="Long P">P.M. Long</name></author><author><name sortKey="Liu, E T" uniqKey="Liu E">E.T. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y. Lu</name></author><author><name sortKey="Bao, Q" uniqKey="Bao Q">Q. Bao</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Wu, N" uniqKey="Wu N">N. Wu</name></author><author><name sortKey="Cheng, S" uniqKey="Cheng S">S. Cheng</name></author><author><name sortKey="Weng, J" uniqKey="Weng J">J. Weng</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J. Yan</name></author><author><name sortKey="Mei, L" uniqKey="Mei L">L. Mei</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y. Yu</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M. Zhang</name></author><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author><author><name sortKey="Yao, J" uniqKey="Yao J">J. Yao</name></author><author><name sortKey="Lu, Q" uniqKey="Lu Q">Q. Lu</name></author><author><name sortKey="Yao, P" uniqKey="Yao P">P. Yao</name></author><author><name sortKey="Bo, X" uniqKey="Bo X">X. Bo</name></author><author><name sortKey="Wo, J" uniqKey="Wo J">J. Wo</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name></author><author><name sortKey="Hu, S" uniqKey="Hu S">S. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, L" uniqKey="Gao L">L. Gao</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J. Qi</name></author><author><name sortKey="Wei, H B" uniqKey="Wei H">H.B. Wei</name></author><author><name sortKey="Sun, Y G" uniqKey="Sun Y">Y.G. Sun</name></author><author><name sortKey="Hao, B L" uniqKey="Hao B">B.L. Hao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qi, Z" uniqKey="Qi Z">Z. Qi</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Chen, Y J" uniqKey="Chen Y">Y.J. Chen</name></author><author><name sortKey="Zhang, Z H" uniqKey="Zhang Z">Z.H. Zhang</name></author><author><name sortKey="Sun, S W" uniqKey="Sun S">S.w. Sun</name></author><author><name sortKey="Lu, H C" uniqKey="Lu H">H.C. Lu</name></author><author><name sortKey="Zhang, J F" uniqKey="Zhang J">J.F. Zhang</name></author><author><name sortKey="Bu, D B" uniqKey="Bu D">D.B. Bu</name></author><author><name sortKey="Ling, L J" uniqKey="Ling L">L.J. Ling</name></author><author><name sortKey="Chen, R S" uniqKey="Chen R">R.S. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsui, S K" uniqKey="Tsui S">S.K. Tsui</name></author><author><name sortKey="Chim, S S" uniqKey="Chim S">S.S. Chim</name></author><author><name sortKey="Lo, Y M" uniqKey="Lo Y">Y.M. Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z G" uniqKey="Wang Z">Z.G. Wang</name></author><author><name sortKey="Li, L J" uniqKey="Li L">L.J. Li</name></author><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y. Luo</name></author><author><name sortKey="Zhang, J Y" uniqKey="Zhang J">J.Y. Zhang</name></author><author><name sortKey="Wang, M Y" uniqKey="Wang M">M.Y. Wang</name></author><author><name sortKey="Cheng, S Y" uniqKey="Cheng S">S.Y. Cheng</name></author><author><name sortKey="Zhang, Y J" uniqKey="Zhang Y">Y.J. Zhang</name></author><author><name sortKey="Wang, X M" uniqKey="Wang X">X.M. Wang</name></author><author><name sortKey="Lu, Y Y" uniqKey="Lu Y">Y.Y. Lu</name></author><author><name sortKey="Wu, N P" uniqKey="Wu N">N.P. Wu</name></author><author><name sortKey="Mei, L L" uniqKey="Mei L">L.L. Mei</name></author><author><name sortKey="Wang, Z X" uniqKey="Wang Z">Z.X. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chinese Sars Molecular Epidemiology Consortium" uniqKey="Chinese Sars Molecular Epidemiology Consortium">Chinese SARS Molecular Epidemiology Consortium</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Stavrinides, J" uniqKey="Stavrinides J">J. Stavrinides</name></author><author><name sortKey="Guttman, D S" uniqKey="Guttman D">D.S. Guttman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chim, S S" uniqKey="Chim S">S.S. Chim</name></author><author><name sortKey="Tsui, S K" uniqKey="Tsui S">S.K. Tsui</name></author><author><name sortKey="Chan, K C" uniqKey="Chan K">K.C. Chan</name></author><author><name sortKey="Au, T C" uniqKey="Au T">T.C. Au</name></author><author><name sortKey="Hung, E C" uniqKey="Hung E">E.C. Hung</name></author><author><name sortKey="Tong, Y K" uniqKey="Tong Y">Y.K. Tong</name></author><author><name sortKey="Chiu, R W" uniqKey="Chiu R">R.W. Chiu</name></author><author><name sortKey="Ng, E K" uniqKey="Ng E">E.K. Ng</name></author><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author><author><name sortKey="Chu, C M" uniqKey="Chu C">C.M. Chu</name></author><author><name sortKey="Sung, J J" uniqKey="Sung J">J.J. Sung</name></author><author><name sortKey="Tam, J S" uniqKey="Tam J">J.S. Tam</name></author><author><name sortKey="Fung, K P" uniqKey="Fung K">K.P. Fung</name></author><author><name sortKey="Waye, M M" uniqKey="Waye M">M.M. Waye</name></author><author><name sortKey="Lee, C Y" uniqKey="Lee C">C.Y. Lee</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Lo, Y M" uniqKey="Lo Y">Y.M. Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Zheng, B" uniqKey="Zheng B">B. Zheng</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Zeng, F Y" uniqKey="Zeng F">F.Y. Zeng</name></author><author><name sortKey="Chan, C W" uniqKey="Chan C">C.W. Chan</name></author><author><name sortKey="Chan, M N" uniqKey="Chan M">M.N. Chan</name></author><author><name sortKey="Chen, J D" uniqKey="Chen J">J.D. Chen</name></author><author><name sortKey="Chow, K Y" uniqKey="Chow K">K.Y. Chow</name></author><author><name sortKey="Hon, C C" uniqKey="Hon C">C.C. Hon</name></author><author><name sortKey="Hui, K H" uniqKey="Hui K">K.H. Hui</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Li, V Y" uniqKey="Li V">V.Y. Li</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Leung, S W" uniqKey="Leung S">S.W. Leung</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Leung, F C" uniqKey="Leung F">F.C. Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, S H" uniqKey="Yeh S">S.H. Yeh</name></author><author><name sortKey="Wang, H Y" uniqKey="Wang H">H.Y. Wang</name></author><author><name sortKey="Tsai, C Y" uniqKey="Tsai C">C.Y. Tsai</name></author><author><name sortKey="Kao, C L" uniqKey="Kao C">C.L. Kao</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J.Y. Yang</name></author><author><name sortKey="Liu, H W" uniqKey="Liu H">H.W. Liu</name></author><author><name sortKey="Su, I J" uniqKey="Su I">I.J. Su</name></author><author><name sortKey="Tsai, S F" uniqKey="Tsai S">S.F. Tsai</name></author><author><name sortKey="Chen, D S" uniqKey="Chen D">D.S. Chen</name></author><author><name sortKey="Chen, P J" uniqKey="Chen P">P.J. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z. Zhao</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name></author><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y. Zhong</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K. Zhang</name></author><author><name sortKey="Zhang, Y P" uniqKey="Zhang Y">Y.P. Zhang</name></author><author><name sortKey="Boerwinkle, E" uniqKey="Boerwinkle E">E. Boerwinkle</name></author><author><name sortKey="Fu, Y X" uniqKey="Fu Y">Y.X. Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Zheng, K" uniqKey="Zheng K">K. Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, K" uniqKey="Zheng K">K. Zheng</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Zheng, H Y" uniqKey="Zheng H">H.Y. Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, W K" uniqKey="Leung W">W.K. Leung</name></author><author><name sortKey="To, K F" uniqKey="To K">K.F. To</name></author><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author><author><name sortKey="Chan, H L" uniqKey="Chan H">H.L. Chan</name></author><author><name sortKey="Wu, A K" uniqKey="Wu A">A.K. Wu</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N. Lee</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Sung, J J" uniqKey="Sung J">J.J. Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, L" uniqKey="Tang L">L. Tang</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q. Zhu</name></author><author><name sortKey="Qin, E" uniqKey="Qin E">E. Qin</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M. Yu</name></author><author><name sortKey="Ding, Z" uniqKey="Ding Z">Z. Ding</name></author><author><name sortKey="Shi, H" uniqKey="Shi H">H. Shi</name></author><author><name sortKey="Cheng, X" uniqKey="Cheng X">X. Cheng</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C. Wang</name></author><author><name sortKey="Chang, G" uniqKey="Chang G">G. Chang</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q. Zhu</name></author><author><name sortKey="Fang, F" uniqKey="Fang F">F. Fang</name></author><author><name sortKey="Chang, H" uniqKey="Chang H">H. Chang</name></author><author><name sortKey="Li, S" uniqKey="Li S">S. Li</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J. Yu</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Wang, Zhi Gang" sort="Wang, Zhi Gang" uniqKey="Wang Z" first="Zhi-Gang" last="Wang">Zhi-Gang Wang</name></region><name sortKey="Bao, Qi Yu" sort="Bao, Qi Yu" uniqKey="Bao Q" first="Qi-Yu" last="Bao">Qi-Yu Bao</name><name sortKey="Bao, Qi Yu" sort="Bao, Qi Yu" uniqKey="Bao Q" first="Qi-Yu" last="Bao">Qi-Yu Bao</name><name sortKey="Cheng, Su Yun" sort="Cheng, Su Yun" uniqKey="Cheng S" first="Su-Yun" last="Cheng">Su-Yun Cheng</name><name sortKey="Cong, Li Ming" sort="Cong, Li Ming" uniqKey="Cong L" first="Li-Ming" last="Cong">Li-Ming Cong</name><name sortKey="Feng, Ming Guang" sort="Feng, Ming Guang" uniqKey="Feng M" first="Ming-Guang" last="Feng">Ming-Guang Feng</name><name sortKey="Li, Lan Juan" sort="Li, Lan Juan" uniqKey="Li L" first="Lan-Juan" last="Li">Lan-Juan Li</name><name sortKey="Luo, Yun" sort="Luo, Yun" uniqKey="Luo Y" first="Yun" last="Luo">Yun Luo</name><name sortKey="Ru, Miao Gui" sort="Ru, Miao Gui" uniqKey="Ru M" first="Miao-Gui" last="Ru">Miao-Gui Ru</name><name sortKey="Shang, Lei" sort="Shang, Lei" uniqKey="Shang L" first="Lei" last="Shang">Lei Shang</name><name sortKey="Wang, Zan Xin" sort="Wang, Zan Xin" uniqKey="Wang Z" first="Zan-Xin" last="Wang">Zan-Xin Wang</name><name sortKey="Zhang, Yan Jun" sort="Zhang, Yan Jun" uniqKey="Zhang Y" first="Yan-Jun" last="Zhang">Yan-Jun Zhang</name><name sortKey="Zheng, Zhi Hua" sort="Zheng, Zhi Hua" uniqKey="Zheng Z" first="Zhi-Hua" last="Zheng">Zhi-Hua Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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